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TITLE	New antifungal tetrahydrofuran derivatives from a marine sponge-associated fungus Aspergillus sp. LS78
AUTHOR	Yang Liu, Lijian Ding, Ziming Zhang, Xiaojun Yan, Shan He
YEAR	2020
JOURNAL	Fitoterapia
ABSTRACT	Two new tetrahydrofuran derivatives named aspericacids A and B (1 and 2) were isolated from the metabolites produced by the sponge-associated Aspergillus sp. LS78. They represented an unusual type of tetrahydrofuran derivatives, possessing 2,5-disubstituted tetrahydrofuran ring coupled with a chain unsaturated fatty acid. The planar structures of 1 and 2 were determined by HRESIMS, 1D and 2D NMR spectroscopy. The absolute configuration of 1 was assigned using both experimental and computational electronic circular dichroism (ECD). In addition, aspericacid A (1) exhibited in vitro antifungal activity (MIC = 50 μg/mL), but 2 showed not significantly activity against any of the tested strains with the MIC values of 128 μg/mL.
FULL ARTICLE	https://www.sciencedirect.com/science/article/abs/pii/S0367326X20302598
INSTRUMENT	J-810
KEYWORDS	Circular dichroism, Absolute configuration, Natural products, Biochemistry, Pharmaceutical

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