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| TITLE | Bioactive Piperazic Acid-Bearing Cyclodepsipeptides, Lydiamycins E–H, from an Endophytic Streptomyces sp. Associated with Cinnamomum cassia |
|---|---|
| AUTHOR | Weihong Wang, Seungjin Kim, Thi Hanh Nguyen Vu, Ngoc Tung Quach, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Youbin Cho, Hyeseon Jang, Eun Roh, JunI Lee, Eunmo Kang, SongJoo Han, Quyet-Tien Phi, and Heonjoong Kang* |
| YEAR | 2023 |
| JOURNAL | Journal of Natural Products |
| ABSTRACT | A chemical investigation of the endophytic Streptomyces sp. HBQ95, associated with the medicinal plant Cinnamomum cassia Presl, enabled the discovery of four new piperazic acid-bearing cyclodepsipeptides, lydiamycins E–H (1–4), and one known compound (lydiamycin A). Their chemical structures, including absolute configurations, were defined by a combination of spectroscopic analyses and multiple chemical manipulations. Lydiamycins F–H (2–4) and A (5) exhibited antimetastatic activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity. |
| FULL ARTICLE | https://pubs.acs.org/doi/full/10.1021/acs.jnatprod.2c00902 |
| INSTRUMENT | P-2000 |
| KEYWORDS | Absolute configuration,Bacteria,Monomers,Peptides and proteins,Pharmaceuticals |
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