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Two New Glycosides from the Whole Plants of Glechoma hederacea L.
2007 / Chemical and Pharmaceutical BulletinTwo new glycosides, 7S,7′S,8R,8′R-icariol A2-9-O-β-D-glucopyranoside (1) and 4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-(1→6)-β-D-glucopyranoside (2), were isolated from the dried whole plants of Glechoma hederacea L. (Labiatae) together with four known compounds, cistanoside E (3), dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopy...
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Biophysical comparability of the same protein from different manufacturers: A case study using Epoetin alfa from Epogen® and Eprex®
2006 / Journal of Pharmaceutical SciencesThis study focuses on the development and application of biophysical methodology to characterize conformations of Epogen® and Eprex®, the injectable formulations of recombinant human Epoetin alfa produced by different manufacturers and commonly used for the treatment of renal anemia. In these studies Eprex, from prefilled syringes, and Epogen bulk product f...
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Chiral Ionic Liquid that Functions as Both Solvent and Chiral Selector for the Determination of Enantiomeric Compositions of Pharmaceutical Products
2006 / Analytical ChemistryWe have successfully synthesized both enantiomers of a novel chiral ionic liquid, (R)- and (S)-[(3-chloro-2-hydroxypropyl) trimethylammonium][bis((trifluoromethyl)sulfonyl)amide] ((R)- and (S)-[CHTA]+[Tf2N]-) in optically pure form by a simple ion exchange reaction from corresponding chloride salts that are commercially available. In addition to the ease of prepara...
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Terpenoids from Juniperus polycarpus var. seravschanica
2006 / PhytochemistryTwo eudesmanes, two abietanes, two podocarpanes and other nine known compounds were isolated from the dried fruits of Juniperus polycarpus var. seravschanica. Their structures were established on the basis of analysis of spectroscopic evidence. Some of the isolated terpenoids showed antimalarial activity.
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Biodegradable polymeric microspheres with “open/closed” pores for sustained release of human growth hormone
2006 / Journal of Controlled ReleaseA new approach for attaining sustained release of protein is introduced, involving a pore-closing process of preformed porous PLGA microspheres. Highly porous biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres were fabricated by a single water-in-oil emulsion solvent evaporation technique using Pluronic F127 as an extractable porogen. Recombinant h...
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Synthesis and characterization of fluorous (S)- and (R)-1-phenylethylamines that effect heat facilitated resolution of ()-2-(8-carboxy-1-naphthylsulfinyl)benzoic acid via diastereomeric salt formation
2006 / Journal of Fluorine ChemistryPerfluoroalkyl- or nonafluoro-tert-butoxy-alkyl-substituted enantiopure amines having the structure PhCHCH3(NR1R2) [R1 = H, CH3; R2 = (CH2)3C8F17, (CH2)2OC(CF3)3; R1 = R2 = (CH2)3C8F17, (CH2)2OC(CF3)3] are obtained in high yields, when (S)-(−)-1-phenylethylamine is reacted with readily accessible alkylating reagents or fluorous 2° amines (R1 = H; R2 = (CH...
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Unsymmetrical 1,n′-disubstituted ferrocenoyl peptides: convenient one pot synthesis and solution structures by CD and NMR spectroscopy
2005 / New Journal of ChemistryWe present a systematic study on unsymmetrical amino acid derivatives of 1,10 -ferrocene dicarboxylic acid. A convenient and general one pot synthetic procedure is presented in which the unsymmetrical amino acid derivatives are readily separated by column chromatography. The following ferrocene derivatives Fe[C5H4-CO-Aaa1-OMe][C5H4-CO-Aaa2-OMe] with different amino...
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Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human α1-acid glycoprotein
2004 / Bioorganic & Medicinal ChemistryThis paper reports the first experimental evidence on binding of the plant derived curcumin molecule to human α1-acid glycoprotein (AGP), an acute phase protein in blood. Oppositely signed induced circular dichroism (CD) bands measured in the visible spectral region in pH 7.4 phosphate buffer indicate that the protein binds this natural polyphenol molecule in...
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Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life
2003 / Journal of Pharmaceutical SciencesThe kinetics of irreversible aggregation of bovine Granulocyte-Colony Stimulating Factor (bG-CSF) in solution were investigated as a function of temperature (T), concentration, and pH, and analyzed in terms of an Extended Lumry-Eyring model of protein aggregation proceeding via a non-native conformational state. In the spirit of classic Lumry-Eyring models, the obs...
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Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
2003 / PhytochemistryTwo plumbagic acid glucosides, 3′-O-β-glucopyranosyl plumbagic acid and 3′-O-β-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Pl...
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New Oxindole Alkaloids and Iridoid from Carolina jasmine (Gelsemium sempervirens AIT. f.)
2003 / Chemical and Pharmaceutical BulletinThree new gelsedine-type oxindole alkaloids, GS-1, GS-2, and GS-3, and one new iridoid, GSIR-1, were isolated from the stems and leaves of cultivated Carolina jasmine (Gelsemium sempervirens AIT. f.) and their structures were determined by spectroscopic analysis.
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Flavanoids from Caesalpinia pulcherrima
2003 / PhytochemistryTwo new flavanoids, 5,7-dimethoxy-3′,4′-methylenedioxyflavanone and isobonducellin along with 2′-hydroxy-2,3,4′,6′-tetramethoxychalcone, 5,7-dimethoxyflavone and bonducellin were isolated from the aerial parts of Caesalpinia pulcherrima. The structures of the compounds were settled mainly by interpretation of their 1D and 2D NMR spectr...
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Stabilization of proteins by low molecular weight multi-ions
2002 / Journal of Pharmaceutical SciencesA method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that molecules of various sizes containing two to four charges should occasionally bind to unpaired charged sites on the surface of proteins and by crosslinking such residues stabilize the native state of the liganded protein. A simple turbidit...
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Two New Pyrrolidine Alkaloids, Radicamines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR
2001 / Chemical and Pharmaceutical BulletinTwo new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of α-glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the...
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Studies on a Medicinal Parasitic Plant: Lignans from the Stems of Cynomorium songaricum
2001 / Chemical and Pharmaceutical BulletinEight phenolic compounds including two new lignan glucopyranosides together with a known alkaloid were isolated from the stems of Cynomorium songaricum RUPR. (Cynomoriaceae). Their chemical structures were elucidated on the basis of spectral and chemical evidence. The chemotaxonomic significance of these metabolites is discussed.
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