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Structural insights into light harvesting by antenna-containing rhodopsins in marine Asgard archaea
2025 / Nature MicrobiologyAquatic bacterial rhodopsin proton pumps harvest light energy for photoheterotrophic growth and are known to contain hydroxylated carotenoids that expand the wavelengths of light utilized, but these have not been characterized in marine archaea. Here, by combining a marine chromophore extract with purified archaeal rhodopsins identified in marine metagenomes, we ...
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Modulating product selectivity in lignin electroreduction with a robust metallic glass catalyst
2025 / Nature CommunicationsConverting the lignin into value-added chemicals and fuels represents a promising way to upgrade lignin. Here, we present an effective electrocatalytic approach that simultaneously modulates the depolymerization and hydrogenation pathways of lignin model compounds within a single reaction system. By fine-tuning the pH of the electrolyte, we achieve a remarkable s...
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Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery
2025 / Scientific ReportsPirfenidone is an antifibrotic and anti-inflammatory drug used for the management of idiopathic pulmonary fibrosis. The current oral delivery of PD has multiple drawbacks, including first-pass metabolism and gastrointestinal discomfort. Efforts have been made to create nanostructured lipid carriers (NLCs) using solid lipids, liquid lipids, and surfactants through...
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Regulating and Stabilizing Strong Metal-Support Interactions on Ni/TiO2 by Crystal Phase for Ultra-Stable Ethanol Reforming
2024 / Advanced Energy MaterialsThe regulation and stabilization of strong metal-support interactions (SMSI) in high temperature hydrogen-rich reaction condition remains a huge challenge due to its structural sensitivity. Herein, tunable SMSI is constructed and stabilized on TiO2 supported Ni catalysts by TiO2 crystal phase engineering strategy, and then a SMSI-degree-depended ethanol stream re...
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Influence of lemongrass and oregano essential oils and their combination on in vitro ruminal fermentation and green
2025 / Italian Journal of Animal ScienceRuminants play a crucial role in the food chain, but are also considered contributors of green house gas (GHG) emissions . Essential oils (EOs) are emerging as natural feed additives in rumi nants’ nutrition to enhance animal health, performance and reduce environmental footprint. Among EOs, lemongrass (Cymbopogon winterianus) and oregano (Origanum vulgare) E...
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The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice
2025 / Scientific ReportsBile acids (BAs) play important roles in the context of lipid homeostasis and inflammation. Based on extensive preclinical mouse studies, BA signaling pathways have been implicated as therapeutic targets for cardiovascular diseases. However, differences in BA metabolism between mice and humans hamper translation of preclinical outcomes. Recently, we generated Cyp...
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Processing of reactive acrylic thermoplastic resin at elevated temperatures for rapid composite and fiber metal laminate manufacturing
2025 / Journal of Thermoplastic Composite MaterialsThermoplastic polymers are increasingly being used as matrix materials for composites because they offer the advantage of recyclability and joinability over thermoset matrix systems. The polymerization kinetics and gas formation of different precursor mixtures of the liquid acrylic matrix system Elium® were investigated with different initiator contents and at ...
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Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
2025 / Nature CommunicationsObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and...
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Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
2024 / NatureLytic cell death culminates in plasma membrane rupture, which releases large intracellular molecules to augment the inflammatory response. Plasma membrane rupture is mediated by the effector membrane protein ninjurin-1 (NINJ1)1, which polymerizes and ruptures the membrane via its hydrophilic face1,2,3,4. How NINJ1 is restrained under steady-state conditions to en...
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Enhanced Photorefractive Performance by Controlling Ion-Assisted Charge Injection and Accumulation with Random Biphenyl Co-Polymerized Poly(Carbazolyl-Amine)
2024 / Advanced Functional MaterialsIn this study, the synthesis of poly(carbazolyl-amine)s with a random co-polymerized biphenyl group through the Buchwald–Hartwig amination to enhance ion-assisted space-charge-limited current (SCLC) and achieve efficient performance in photorefractive (PR) polymers, is reported. By modulating the polymer crystallinity, the efficient accumulation of ions nea...
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Proton transfer anionic polymerization with C–H bond as the dormant species
2024 / Nature ChemistryLiving anionic polymerization—the most common living polymerization and the one with the longest history—generally requires stringent, water-free conditions and one metal initiator per polymer chain. Here we present the proton transfer anionic polymerization of methacrylates using acidic C–H bonds as the dormant species that are activated by base ...
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Brain physiology during photoperiod-related caste determination in the primitively eusocial wasp Polistes jokahamae
2024 / Scientific ReportsAdult females of the primitively eusocial wasp Polistes jokahamae can change caste in response to photoperiod length. Short-day photoperiod females store more lipids but have less developed ovaries for hibernation (becoming gynes), whereas long-day photoperiod females have fewer lipid stores but more developed ovaries under queenless conditions (becoming egg-layi...
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Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential
2024 / Scientific ReportsIn this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-derivatized oxindoles and a unique zwitterionic amidine featuring a nido-cluster. We tested the anti-cancer po...
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Dyeing of synthetic fiber-based wool blended fabrics in supercritical carbon dioxide
2024 / Scientific ReportsDevelopment of supercritical carbon dioxide (SC-CO2) dyeing technology for natural fabrics and their blended fabrics is essential for the textile industry due to environmental and economic considerations. Wool (W), polyester (PET) and nylon (N) fabrics and their wool/polyester (W/PET) and wool/nylon (W/N) blended fabrics were dyed in SC-CO2 medium with a synthesi...
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Nanoparticles Combining Host-Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum
2024 / Advanced TherapeuticsThe bacterial pathogen, Mycobacterium tuberculosis (Mtb), remains a leading cause of global morbidity and mortality. Due to the complexity of the infection, the limited efficacy of antibiotics, and the increasing incidence of multi-drug resistant strains, novel therapeutics are urgently needed. An interesting new approach is to combine antibiotics with treatments t...
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