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| TITLE | Solar-hybrid biocatalyst for methane hydroxylation to methanol |
|---|---|
| AUTHOR | Jinha Jang, Devashish Das, Rowina Lestari, Jung-Kul Lee & Chan Beum Park |
| YEAR | 2025 |
| JOURNAL | Nature Communications |
| ABSTRACT | Methane hydroxylation presents a promising approach to produce high-energy methanol from potent greenhouse gases, thereby contributing to a more sustainable future. Despite its environmental importance, current research on this process remains challenging due to the harsh operating conditions for the activation of inert C-H bond in methane. In nature, methane monooxygenase converts methane by activating the C-H bonds through its hydroxylase, under ambient conditions, receiving electrons from NADH via a reductase. Beyond the traditional biological approach, the development of NADH-independent biocatalytic systems could open new avenues for cost-effective and sustainable methane conversion. Herein, we report an NADH-free biosolar platform that activates hydroxylase for eco-friendly methanol production. The xanthene-based light harvester spontaneously associates with hydroxylase and directly transfers its photoexcited electrons to the diiron active site, eliminating the need for a cofactor or reductase. Halogenation of xanthene accelerates direct electron transfer to the active site by increasing the polarizability and spin-orbit coupling of the light harvesters. Accordingly, the direct photobiocatalytic platform achieved a methanol time yield of 7.52 mmol gcat−1 h−1. This work provides the design concept of solar-driven biocatalytic methane hydroxylation under ambient conditions, suggesting a promising approach for implementing methanol biomanufacturing. |
| FULL ARTICLE | https://www.nature.com/articles/s41467-025-64362-6 |
| INSTRUMENT | V-650 |
| KEYWORDS | Biocatalysis |
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