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| TITLE | Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics |
|---|---|
| AUTHOR | Duy-Thuc Nguyen, Min-Jun Baek, Sang Min Lee, Dahan Kim, So-Yeol Yoo, Jae-Young Lee & Dae-Duk Kim |
| YEAR | 2024 |
| JOURNAL | Nature Nanotechnology |
| ABSTRACT | Although charge-converting nanoparticles (NPs) potentially penetrate tumours deeply, conventional charge conversion strategies possess limitations, including low selectivity and slow, inconsistent conversion rate within the tumour microenvironment. In this study, we synthesized a zwitterionic near-infrared cyclodextrin derivative of heptamethine cyanine and complexed it with pheophorbide-conjugated ferrocene to produce multifunctional theranostic nanotherapeutics. Our NPs demonstrated enhanced tumour-targeting ability, enabling the highly specific imaging of rectal tumours, with tumour-to-rectum signal ratios reaching up to 7.8. The zwitterionic surface charge of the NPs was rapidly converted to a cationic charge within the tumours on 880 nm near-infrared laser irradiation, promoting the tumoural penetration of NPs via transcytosis. After penetration, photodynamic/chemodynamic therapy was initiated using a 660 nm laser. Our NPs eradicated clinically relevant-sized heterotopic tumours (~250 mm3) and orthotopic rectal tumours, displaying their potential as theranostic nanoplatforms for targeting rectal cancer. |
| FULL ARTICLE | https://www.nature.com/articles/s41565-024-01757-4 |
| INSTRUMENT | FP-8350 |
| KEYWORDS | Drug delivery, Nanotechnology in cancer |
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