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Found 756 Results / Page 51 of 51
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Flavanoids from Caesalpinia pulcherrima
2003 / PhytochemistryTwo new flavanoids, 5,7-dimethoxy-3′,4′-methylenedioxyflavanone and isobonducellin along with 2′-hydroxy-2,3,4′,6′-tetramethoxychalcone, 5,7-dimethoxyflavone and bonducellin were isolated from the aerial parts of Caesalpinia pulcherrima. The structures of the compounds were settled mainly by interpretation of their 1D and 2D NMR spectr...
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Stabilization of proteins by low molecular weight multi-ions
2002 / Journal of Pharmaceutical SciencesA method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that molecules of various sizes containing two to four charges should occasionally bind to unpaired charged sites on the surface of proteins and by crosslinking such residues stabilize the native state of the liganded protein. A simple turbidit...
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Two New Pyrrolidine Alkaloids, Radicamines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR
2001 / Chemical and Pharmaceutical BulletinTwo new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of α-glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the...
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Studies on a Medicinal Parasitic Plant: Lignans from the Stems of Cynomorium songaricum
2001 / Chemical and Pharmaceutical BulletinEight phenolic compounds including two new lignan glucopyranosides together with a known alkaloid were isolated from the stems of Cynomorium songaricum RUPR. (Cynomoriaceae). Their chemical structures were elucidated on the basis of spectral and chemical evidence. The chemotaxonomic significance of these metabolites is discussed.
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Cytotoxic Lavandulyl Flavanones from Sophora flavescens
2000 / Journal of Natural ProductsTwo new lavandulylated flavanones, (2S)-2‘-methoxykurarinone (1) and (−)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin andl-maakiain. The structures of 1 and 2 were determined on the basis of optical...
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Protein stabilising effect of polyethyleneimine
1999 / Journal of BiotechnologyThe effect of polyethyleneimine (PEI), a cationic polymer, on protein stability was investigated. Shelf stability of lactate dehydrogenase, stored as an aqueous solution, at 36°C was distinctly improved in the presence of 0.01–1% (w/v) polymer (except at pH 5.0). PEI also prevented aggregation of the protein during long-term storage. Both high and low mol...
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