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Found 10,426 Results / Page 216 of 696
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Zein coated calcium carbonate nanoparticles for the targeted controlled release of model antibiotic and nutrient across the intestine
2020 / Materials Today CommunicationsIn this study, a novel bio-inspired method was used to synthesize calcium carbonate nanoparticles (CaCO3 NPs) using gelatin as a template for the co-delivery of vitamin D and amoxicillin. The synthesized CaCO3 NPs were characterized using Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Thermogravimetr...
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Novel Isatin Thiosemicarbazone Derivatives as Potent Inhibitors of β-Amyloid Peptide Aggregation and Toxicity
2020 / ACS Chemical NeuroscienceInhibition of β-amyloid peptide (Αβ) aggregation in Alzheimer’s disease (AD) is among the therapeutic approaches against AD which still attracts scientific research interest. In the search for compounds that interact with Aβ and disrupt its typical aggregation course toward oligomeric or polymeric toxic assemblies, small organic molecules...
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Highly Distorted Chiral Two-Dimensional Tin Iodide Perovskites for Spin Polarized Charge Transport
2020 / JACSIncorporating chiral organic molecules into organic/inorganic hybrid 2D metal-halide perovskites results in a novel family of chiral hybrid semiconductors with unique spin-dependent properties. The embedded chiral organic moieties induce a chiroptical response from the inorganic metal–halide sublattice. However, the structural interplay between the chiral org...
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Synthesis and anti-osteoporosis activity of novel Teriparatide glycosylation derivatives
2020 / RSC AdvancesOsteoporosis is a metabolic bone disease that is characterized by low bone mass and micro-architectural deterioration of bones. The mechanism underlying this disease implicates an imbalance between bone resorption and bone remodeling. In 2002, the US Food and Drug Administration (FDA) approved Teriparatide for the treatment of osteoporosis, and so far, this compoun...
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21-Epi-taichunamide D and (±)-versicaline A, three unusual alkaloids from the endophytic Aspergillus versicolor F210
2020 / Tetrahedron LettersThree new alkaloids, 21-epi-taichunamide D (1) and (±)-versicalin A ((±)-6), along with four known analogues (2–5) were isolated from the endophytic Aspergillus versicolor F210, which harbored in the bulbs of Lycoris radiata. Structurally, compound 1 is the third natural indole alkaloid with a rare methylsulfonyl unit, and (±)-6 existing ...
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Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin
2020 / European Journal of Pharmaceutical SciencesWith the increment of drug-resistant bacteria and the slow development of novel antibiotics, antimicrobial peptides have gained increasing attention as a potential antibiotic alternative. They not only displayed a broad-spectrum antimicrobial activity but also were difficult to induce resistance development because of their unique membrane-lytic activity. Herein, t...
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Multitargeting Antibacterial Activity of a Synthesized Mn2+ Complex of Curcumin on Gram-Positive and Gram-Negative Bacterial Strains
2020 / ACS OmegaCurcumin is an important molecule with a plethora of pharmacological activities and therapeutic potentials. Despite its efficacy, it remained a potential drug candidate owing to hydrolytic instability and poor aqueous solubility. To overcome the limitations related to low solubility, low bioavailability, and the fact that curcumin is never present in solution as a ...
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A Glucose binding lectin from Leucaena leucocephala seeds and its mitogenic activity against human lymphocytes
2020 / International Journal of Biological MacromoleculesLectins are a specialized group of proteins with immense biological properties and applications. This study describes the purification and characterization of a lectin from Leucaena leucocephala seeds, a plant belonging to the Fabaceae family. Leucaena leucocephala lectin (LLL) was purified by a two-step purification method involving DEAE-cellulose anion exchange c...
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Feasibility of collagens obtained from bester sturgeon Huso huso × Acipenser ruthenus for industrial use
2020 / AquacultureTo increase the value of bester sturgeon (a hybrid of Huso huso × Acipenser ruthenus) and promote development of the sturgeon aquaculture industry, this study assessed the feasibility of using collagens from bester sturgeon by-products for industrial applications. We first found that individual stable characteristics in terms of yield, amino acid composition,...
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Lignin nanoparticles as a promising vaccine adjuvant and delivery system for ovalbumin
2020 / International Journal of Biological MacromoleculesVaccination is the most effective strategy of preventing and treating infectious diseases and the most significant issue in the development of potent vaccines is the sufficient immunogenicity and safety of vaccines. The main goal of the present study is to develop a potent and safe vaccine adjuvant that can also stabilize antigen formulations during preparation and...
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Enhanced visible light absorption of TiO2 nanorod photoanode by NiTiO3 decoration for high-performance photoelectrochemical cells
2020 / Ceramics InternationalTiO2 nanorod (NR) and NiTiO3 (NTO) enhanced TiO2 NR photoanodes were studied for visible light driven water splitting in photoelectrochemical cells (PECs). The TiO2 and NTO/TiO2 growth on the FTO substrates were synthesised via the hydrothermal method. The Ni2+ content was the control factor to fabricate various different NTO/TiO2 heterostructures. The structure an...
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Influence of precursor ratio and dopant concentration on the structure and optical properties of Cu-doped ZnCdSe-alloyed quantum dots
2020 / RSC AdvancesTunable copper doped Zn1−xCdxS alloy quantum dots (QDs) were successfully synthesized by the wet chemical method. A one-step method is developed to synthesize doped ternary QDs which is more preferable than a two-step method. The influence of experimental parameters like the Zn/Cd ratio and Cu dopant concentration has been investigated using various spectrosc...
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Application of real sample analysis and biosensing: Synthesis of new naphthyl derived chemosensor for detection of Al3+ ions
2020 / Spectrochimica Acta Part A: Molecular and Biomolecular SpectroscopyA new chemosensor (NANH) based on naphthyl moiety was synthesized with good selectivity and sensitivity towards Al3+ ions via the inhibition by operating through dual mechanisms like photo-induced electron transfer (PET) and excited-state intramolecular proton transfer (ESIPT). The synthesized NANH was validated by various techniques such as 1H, 13C NMR and mass sp...
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Wrapping Chiral Nanoribbons into Coiled and Condensed Microstructures in Supramolecular Hydrogels
2020 / Advanced Functional MaterialsHierarchical self‐assembly of small molecules into supramolecular structures across various length scales is of prominent importance to deeply understand and mimic the biological systems. Here, chiral nanoribbons that assembled from chiral phenylalanine and achiral coumarin derivatives can curve and grow into higher ordered hollow microstructures, which exhibit enh...
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Simple and non-charged long-lived fluorescent intracellular organelle trackers
2020 / Dyes and PigmentsIn this work the preferential accumulation of long-lived acridone derivatives in mitochondria were evaluated, based on a new concept of non-protonable and non-charged group carriers. In this sense, the thiophene ring has been proved to act, for the first time, as mitochondria targeting group. Moreover, the unique long lifetime of the dyes has allowed the determinat...
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