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Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases
2025 / Nature CommunicationsThe biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) involves binding of the N-terminal leader region of precursor peptides to peptide-modifying enzymes and subsequent modification of the C-terminal core. Canonical RiPP leaders are short and unstructured. However, atypical RiPP leaders called nitrile hydratase-like leader...
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Tailored structured peptide design with a key-cutting machine approach
2025 / Nature Machine IntelligenceComputational protein and peptide design is emerging as a transformative framework for engineering macromolecules with precise structures and functions, offering innovative solutions in medicine, biotechnology and materials science. However, current methods predominantly rely on generative models, which are expensive to train and modify. Here, we introduce the Ke...
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Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction
2025 / Nature CommunicationsThe existence of linear cholesterol-recognition motifs in transmembrane domains has long been debated. Evolutionary molecular dynamics (Evo-MD) simulations—genetic algorithms guided by (coarse-grained) molecular force-fields–reveal that thermodynamic optimal cholesterol attraction in isolated alpha-helical transmembrane domains occurs when multiple co...
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Chiral recognition via symmetry-dependent luminescence in zero-dimensional hybrid copper halides
2025 / Nature CommunicationsChiral recognition through fluorescence changes enables the rapid and sensitive determination of enantiomers. However, the rational design and synthesis of fluorescent probes for efficient chiral recognition remain a challenge. Here we present a novel platform for chiral recognition based on zero-dimensional hybrid copper halides with unique symmetry-dependent pr...
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Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics
2025 / Nature Biomedical EngineeringGene-silencing mechanisms using RNA interference (RNAi) and antisense oligomers have drawn attention to nucleic acid medicines. However, several challenges remain such as low in vivo stability and inadequate target selectivity. Here we report a versatile and highly selective method for suppressing gene expression with a short oligonucleotide. The oligonucleotide,...
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Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction
2025 / Nature CommunicationsThe accumulation of intracellular aggregates of Tau protein is one main hallmark of Alzheimer’s disease (AD) and is the consequence of Tau conformational changes, increased phosphorylation, and self-association to form fibrillar aggregates. This pathological process prevents the physiological interaction of Tau with microtubules to the detriment of the stru...
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Effects of solution conditions on the self-assembly of the chaperone protein DNAJB6b
2025 / Communications ChemistryChaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone sel...
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Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation
2025 / Nature CommunicationsTriplet-triplet annihilation photon upconversion seeks efficient conversion of low-energy photons to high-energy emission. However, the triplet-triplet annihilation photon upconversion system faces limitations in emission gamut because efficient triplet-triplet energy transfer between sensitizer and annihilator relies on triplet energy matching, making it challen...
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Design of circularly polarized phosphorescence materials guided by transfer learning
2025 / Nature CommunicationsIt is highly desirable that artificial circularly polarized phosphorescent materials with high luminescence asymmetry factor (glum), narrowband emission and tunable chiral phosphorescent performance can be constructed. Especially, precise control and simultaneous independent switching of circularly polarized fluorescent and phosphorescent performance for the same...
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Albumin Corona Overturns Long-Acting Behaviors of Myristic Acid-Conjugated Quetiapine Nanosuspension
2025 / Advanced Healthcare MaterialsThis work aimed to investigate the interaction of a self-assembled myristic acid-conjugated quetiapine nanosuspension (QMN) with human serum albumin and its overturning effect on QMN’s long-acting performance. Albumin corona formation modified the physicochemical properties and pharmacokinetic profile of QMN by overturning its pH-responsiveness and nano-aggre...
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Rational Design Principles for De Novo α-Helical Peptide Barrels with Dynamic Conductive Channels
2025 / Journal of the American Chemical SocietyDespite advances in peptide and protein design, the rational design of membrane-spanning peptides that form conducting channels remains challenging due to our imperfect understanding of the sequence-to-structure relationships that drive membrane insertion, assembly, and conductance. Here, we describe the design and computational and experimental characterization of...
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Cathelicidin-BF: A Potent Antimicrobial Peptide Leveraging Charge and Phospholipid Recruitment against Multidrug-Resistant Clinical Bacterial Isolates
2025 / Journal of the American Chemical SocietyCathelicidin-BF (CatBF) is a LL-37 homologous antimicrobialpeptide(AMP) isolatedfromBungarus fasciatuswith anexceptional portfolioof antimicrobial, antiviral, antifungal, and anticancer activities. Contrary tomanyAMPs, it showeda good pharmacologicalprofilewithahalf-lifeofat least1hinserumand efficacyagainstbacterial infectionsinmice.Toevaluateitspotential against ...
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A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
2025 / Advanced Functional MaterialsInsufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed of superoxide dismutase (SOD) and catalase (CAT) conjugated within a single poly(ε-caprolactone) (PCL) nanoparticle is ...
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Fabrication of a Lipopolysaccharide-Targeting Peptide-Based Colloid for Alleviating Carbapenem-Resistant Enterobacteriaceae-Induced Cutaneous Infection
2025 / Advanced Healthcare MaterialsCarbapenem-resistant Enterobacteriaceae (CRE) becomes a growing threat to human health. Many clinical isolates have shown strong resistance to commonly used antibacterial agents. Inspired by cationic amphiphiles with tandem-repeat sequence, two novel peptides termed IW (IWRRIWRRIWRRIWRR-NH2) and WI (WIRRWIRRWIRRWIRR-NH2)are designed, synthesized, and investigated i...
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A self-assembled protein β-helix as a self-contained biofunctional motif
2025 / Nature CommunicationsNature constructs matter by employing protein folding motifs, many of which have been synthetically reconstituted to exploit function. A less understood motif whose structure-function relationships remain unexploited is formed by parallel β-strands arranged in a helical repetitive pattern, termed a β-helix. Herein we reconstitute a protein β-helix ...
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