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Found 10,426 Results / Page 68 of 696
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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity
2023 / Communications ChemistrySeleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological properties that differ from those of Ins. Previously, we pioneered the development of a [C7UA,C7UB] analog of bovine pa...
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Site-activatable targeting of macromolecular alendronate for accelerated fracture healing
2023 / Science and Technology of Advanced MaterialsSustainable social activity is a major goal in an aging society, although this is limited by loss of athleticism, with osteoporosis-related fractures being the most common cause of long-term behavioral restrictions in older people. Therefore, the development of therapeutics that shorten the duration of fracture therapy is essential to improve the quality of life an...
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Synthetic Collagen Hydrogels through Symmetric Self-Assembly of Small Peptides
2023 / Advanced ScienceAnimal-sourced hydrogels, such as collagen, are widely used as extracellular-matrix (ECM) mimics in tissue engineering but are plagued with problems of reproducibility, immunogenicity, and contamination. Synthetic, chemically defined hydrogels can avoid such issues. Despite the abundance of collagen in the ECM, synthetic collagen hydrogels are extremely rare due to...
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Spider-Silk-Inspired Tough, Self-Healing, and Melt-Spinnable Ionogels
2023 / Advanced ScienceAs stretchable conductive materials, ionogels have gained increasing attention. However, it still remains crucial to integrate multiple functions including mechanically robust, room temperature self-healing capacity, facile processing, and recyclability into an ionogel-based device with high potential for applications such as soft robots, electronic skins, and wear...
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Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides
2023 / Nature CommunicationsAntibiotics are central to modern medicine, and yet they are mainly the products of intra and inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a common mechanism of action, we investigated the origins of an extremely valuable class of compounds, lipid II targeting glycopeptide antibiotics (GPAs, exemplified by teicoplanin an...
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Spectrofluorometric quantitative analysis of aripiprazole based on quenching of natural derived carbon quantum dots in spiked human plasma
2023 / Scientific ReportsAutism spectrum disorder is a significant concern worldwide, particularly in Middle Eastern countries. Aripiprazole, a psychiatric medicine that works as a partial agonist at D2 receptors, is often used for autism-related behavior issues in children. Monitoring the therapy of aripiprazole could enhance the safety and effectiveness of treatment for autistic indivi...
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Olive stone as an eco-friendly bio-adsorbent for elimination of methylene blue dye from industrial wastewater
2023 / Scientific ReportsAdsorbents synthesized by activation and nanoparticle surface modifications are expensive and might pose health and ecological risks. Therefore, the interest in raw waste biomass materials as adsorbents is growing. In batch studies, an inexpensive and effective adsorbent is developed from raw olive stone (OS) to remove methylene blue (MB) from an aqueous solution...
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Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy
2023 / Advanced ScienceNano-sized contrast agents (NCAs) hold potential for highly specific tumor contrast enhancement during magnetic resonance imaging. Given the quantity of contrast agents loaded into a single nano-carrier and the anticipated relaxation effects, the current molecular design approaches its limits. In this study, a novel molecular mechanism to augment the relaxation of ...
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New cytotoxic dammarane type saponins from Ziziphus spina-christi
2023 / Scientific ReportsCancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F. Rhamnaceae) leaf extract afforded two new dammarane type saponins identified as christinin E and F (1, 2), along wi...
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Periplasmic chitooligosaccharide-binding protein requires a three-domain organization for substrate translocation
2023 / Scientific ReportsPeriplasmic solute-binding proteins (SBPs) specific for chitooligosaccharides, (GlcNAc)n (n = 2, 3, 4, 5 and 6), are involved in the uptake of chitinous nutrients and the negative control of chitin signal transduction in Vibrios. Most translocation processes by SBPs across the inner membrane have been explained thus far by two-domain open/closed mec...
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Novel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria
2023 / Communications BiologyThe WYL domain is a nucleotide-sensing module that controls the activity of transcription factors involved in the regulation of DNA damage response and phage defense mechanisms in bacteria. In this study, we investigated a WYL domain-containing transcription factor in Mycobacterium smegmatis that we termed stress-involved WYL domain-containing regulator (SiwR). W...
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A new β-cyclodextrin-based nickel as green and water-soluble supramolecular catalysts for aqueous Suzuki reaction
2023 / Scientific ReportsA water-soluble nickel complex based on amino-β-CD was developed using a facile method and exhibits excellent catalytic performance in the Suzuki reaction in water. This synthesized complex has been characterized using UV–Vis, AAS, TGA, and FT-IR techniques. The easily synthesized novel supramolecular catalysts have been applied as a green and eco-frie...
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Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry
2023 / Nature CommunicationsOff-target interactions between antisense oligonucleotides (ASOs) with state-of-the-art modifications and biological components still pose clinical safety liabilities. To mitigate a broad spectrum of off-target interactions and enhance the safety profile of ASO drugs, we here devise a nanoarchitecture named BRace On a THERapeutic aSo (BROTHERS or BRO), which is c...
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Gradient tungsten-doped Bi3TiNbO9 ferroelectric photocatalysts with additional built-in electric field for efficient overall water splitting
2023 / Nature CommunicationsBi3TiNbO9, a layered ferroelectric photocatalyst, exhibits great potential for overall water splitting through efficient intralayer separation of photogenerated carriers motivated by a depolarization field along the in-plane a-axis. However, the poor interlayer transport of carriers along the out-of-plane c-axis, caused by the significant potential barrier betwee...
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Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
2023 / Natural Products and BioprospectingFour highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A–C possess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran motif. Kaemtakol D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltricyclo[3.2.1.02,7]octene r...
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