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Impact of C- and N-terminal protection on the stability, metal chelation and antimicrobial properties of calcitermin
2023 / Scientific ReportsThe main limitation to the use of antimicrobial peptides (AMPs) as regular drugs, against antibiotic and antifungal resistance, mainly relates to their rapid degradation by proteolytic enzymes. The introduction of suitable structural changes in the peptide chain can make the peptide less susceptible to the action of proteases, thus overcoming this problem. To imp...
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Origin of fast charging in hard carbon anodes
2023 / Nature EnergyTransport electrification and grid storage hinge largely on fast-charging capabilities of Li- and Na-ion batteries, but anodes such as graphite with plating issues drive the scientific focus towards anodes with slopped storage potentials. Here we report fast charging of ampere-hour-level full Na-ion batteries within about 9 minutes for continuous 3,000 cyc...
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Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates
2023 / Scientific ReportsSARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimic the compact, prefusion conformation of the spike on the virus surface. Since 2020, we have produced dozens of such constru...
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Cocultures of Enterococcus faecium and Aeromonas veronii Induce the Secretion of Bacteriocin-like Substances against Aeromonas
2023 / Journal of Agricultural and Food ChemistryLactic acid bacteria (LAB) were screened from Lutjanus russellii (red sea bass), and their antimicrobial activities were evaluated against two Aeromonas species isolated from the Nile tilapia, namely, Aeromonas veronii (AV) and Aeromonas jandaei (AJ). Three LAB isolates, Enterococcus faecium MU8 (EF_8), Enterococcus faecalis MU2 (EFL_2), and E. faecalis MU9 (EFL_9)...
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Liquid spherical shells are a non-equilibrium steady state of active droplets
2023 / Nature CommunicationsLiquid-liquid phase separation yields spherical droplets that eventually coarsen to one large, stable droplet governed by the principle of minimal free energy. In chemically fueled phase separation, the formation of phase-separating molecules is coupled to a fuel-driven, non-equilibrium reaction cycle. It thus yields dissipative structures sustained by a continuo...
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Identification of the functional PD-L1 interface region responsible for PD-1 binding and initiation of PD-1 signaling
2023 / Journal of Biological ChemistryThe PD-1/PD-L1 checkpoint pathway is important for regulating immune responses and can be targeted by immunomodulatory drugs to treat a variety of immune disorders. However, the precise protein–protein interactions required for the initiation of PD-1/PD-L1 signaling are currently unknown. Previously, we designed a series of first-generation PD-1 targeting p...
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Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies
2023 / Scientific ReportsWe designed and prepared a novel series of urea derivatives with/without sulfonyl group in their structures to investigate the impact of the sulfonyl group on the biological activity of the evaluated compounds. Antibacterial investigations indicated that derivatives 7, 8, 9, and 11 had the most antibacterial property of all the compounds examined, their minimum i...
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Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers
2023 / Journal of Medicinal Chemistryv FR901464 is a cytotoxic natural product that binds splicing factor 3B subunit 1 (SF3B1) and PHD finger protein 5A (PHF5A), the components of the human spliceosome. The amide-containing tetrahydropyran ring binds SF3B1, and it remains unclear how the substituents on the ring contribute to the binding. Here, we synthesized meayamycin D, an analogue of FR901464, ...
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
2023 / Nature CommunicationsLiquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and nucleic acids) into membraneless organelles in cells. Unstructured and intrinsically disordered domains are known to facilitate multivalent interactions driving protein LLPS. We hypothesized that LLPS could be a...
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Inverse design of chiral functional films by a robotic AI-guided system
2023 / Nature CommunicationsArtificial chiral materials and nanostructures with strong and tuneable chiroptical activities, including sign, magnitude, and wavelength distribution, are useful owing to their potential applications in chiral sensing, enantioselective catalysis, and chiroptical devices. Thus, the inverse design and customized manufacturing of these materials is highly desirable...
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Radiolytically reworked Archean organic matter in a habitable deep ancient high-temperature brine
2023 / Nature CommunicationsInvestigations of abiotic and biotic contributions to dissolved organic carbon (DOC) are required to constrain microbial habitability in continental subsurface fluids. Here we investigate a large (101–283 mg C/L) DOC pool in an ancient (>1Ga), high temperature (45–55 °C), low biomass (102−104 cells/mL), and deep (3.2&...
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Highly efficient lead removal from water by Nd0.90Ho0.10FeO3 nanoparticles and studying their optical and magnetic properties
2023 / Scientific ReportsHo-doped NdFeO3 was synthesized using the citrate method. The X-ray diffraction (XRD) illustrated that Nd0.90Ho0.10FeO3 was crystalline at the nanoscale, with a crystallite size of 39.136 nm. The field emission scanning electron microscope (FESEM) illustrated the porous nature of Nd0.90Ho0.10FeO3, which increases the active sites to absorb the heavy metals on the...
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A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome
2023 / Scientific ReportsAn animal-like cryptochrome derived from Chlamydomonas reinhardtii (CraCRY) is a bifunctional flavoenzyme harboring flavin adenine dinucleotide (FAD) as a photoreceptive/catalytic center and functions both in the regulation of gene transcription and the repair of UV-induced DNA lesions in a light-dependent manner, using different FAD redox states. To address how ...
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Synergistic Approach of Antibody-Photosensitizer Conjugate Independent of KRAS-Mutation and Its Downstream Blockade Pathway in Colorectal Cancer
2023 / Advanced Healthcare MaterialsHere, a novel approach is presented to improve the efficacy of antibody-drug conjugates (ADC) by integrating antibody-mediated immunotherapy and photodynamic therapy (PDT) in a combination therapy system utilizing an antibody-photosensitizer conjugate (APC) platform based on a poloxamer polymer linker. To specifically target Kirsten rat sarcoma 2 viral oncogene h...
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Double-Side Passivation of Perovskite Solar Cells for High Performance and Stability
2023 / Advacned Functional MaterialsPerovskite solar cells (PSCs) are in the spotlight as promising renewable energy devices by their appealing properties. However, they face challenges both in power conversion efficiency (PCE) and long-term stability. The presence of surface defects in the PSCs is a significant obstacle to achieving both high efficiency and stability, as these defects cause nonrad...
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