JASCO | Circular Dichroism Detector [ CD-4095 ]
→ The CD-4095 is a unique HPLC CD detector for measuring circular dichroism developed from the market leading J-Series circular dichroism spectropolarimeters. Optically active compounds with a chromophore close to a chiral center may absorb circularly polarized light, which can be detected with excellent sensitivity and selectivity. When chiral compounds are measured using a UV-Visible detector, the d- and l- enantiomers cannot be distinguished even when separated by a chiral column, however the CD-4095 CD detector makes it possible to positively distinguish between the d- and l- enantiomers by measuring their positive and negative peaks.
It is also possible to quantify the d- and l-forms even when they are not separated; a calibration curve based on the g-factor can be used to determine the enantiomeric ratio. ChromNAV CDS can be used to simultaneously measure the CD, g-factor data and UV-visible signals. The CD spectra of eluted compounds can be measured by triggering scanning manually, by timed program or automatically by threshold.
The CD-4095 can be used with SFC and HPLC.
