JASCO | Circular Dichroism
TS Science
Product
[CD] Circular Dichroism
J-1500
J-1500 Circular Dichroism Spectrophotometer
The J-1500 allows for the maximum flexibility to upgrade your CD system with different measurement techniques. While the standard measurement modes are CD, LD, and absorbance, up to four simultaneous modes can be measured when combined with a wide range of sampling accessories.
These accessories can measure a variety of samples, from liquids to films to solid-states. Temperature control systems can be coupled with multi-position cells to run thermal melts, providing researchers with CD and thermodynamic data sets for conformational and folding studies. Automated high-throughput CD can obtain measurements on up to 192 samples without user intervention, saving both time and money. Kinetic and protein dynamics studies can be performed with our dedicated stopped-flow systems that can measure both CD and fluorescence.
The wavelength range has also been significantly extended, allowing measurements to be obtained in both the vacuum-UV and NIR spectral regions using the standard PMT detector (163 – 950 nm) and an optional InGaAs detector (up to 1600 nm). Additional features now allow researchers to optimize their parameter specifications in order to obtain data with the highest resolution and S/N performance for a specific application set.
System Features
The innovative optical system of the J-1500 permits the measurement of a CD spectrum in the vacuum-UV region down to 163 nm. The enhanced light throughput and new digital lock-in technology now allows for a small signal to be detected in a very noisy environment. Additionally, the optimization of the nitrogen purge efficiency helps to reduce the amount of oxygen in the optical bench so it does not bury the sample signal.
These features ensure that CD spectra can be obtained from strongly absorbing and high signal-to-noise (S/N) samples across the spectrum and into the vacuum-UV region. The quality of spectral data obtained, including data obtained at shorter wavelengths, substantially improves the accuracy of protein secondary structure analysis.
Rapid Scanning
High sensitivity combined with a 10,000 nm-per-minute maximum scan speed allows the J-1500 to measure samples quickly, increasing productivity in your lab. An additional benefit is the minimal time exposure of biological samples to the high-energy UV light, minimizing the risk of sample degradation. A mechanical shutter can also be programmed to open and close only during actual measurement to further avoid UV exposure.
Simultaneous Multi-Probe Measurements
The latest quad-channel lock-in amplifier provides simultaneous acquisition of up to four data channels including CD, HT, DC, absorbance, linear dichroism (LD), fluorescence, fluorescence-detected CD (FDCD), fluorescence-detected LD (FDLD) and fluorescence anisotropy.
Additionally, the lock-in amplifier obtains a signal at a specific resonance frequency while filtering out noise signals at other frequencies, providing spectra with excellent signal-to-noise ratios.
Specification
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