Product

[CD] Circular Dichroism

[CD]Automated Titration

JASCO | Automated Titration

 

· Automated Titration Accessory

 

→ CD spectroscopists have often looked at changes in CD signal due to changes in solvent composition such as pH and buffer. In addition the studies of binding are also often of interest including protein-protein interactions as well as DNA and ligand binding.

While these studies are often performed manually the use of automated titration systems has become more popular.

 

 

1. ATS-530 | Automated Titration Unit

The ATS-530 is designed to automatically monitor changes in CD, absorbance and fl uorescence as a function of solution pH, chemical denaturant, or exogenous ligands in experiments such as protein denaturation or ligand binding. Dual syringes are employed, each equipped with a valve for automated refi lling/fl ushing during extended runs and for maintaining a constant cell volume. Additionally, the titration measurement program automatically corrects for concentration.

The ATS-530 utilizes a 10 mm rectangular cell for mixing. It can be used with the PTC-517 or one position in either the MPTC-513 or the MPTC-511 Peltier cell holders.

• Automated titration measurement program included

• Macro command for complex/custom titrations

• Dual syringes (1 mL volume (standard), 1000 steps/syringe)

• Stirrer provided for mixing

• Temperature control

• Constant cell volume

• Concentration correction

• pH measurement (optional)

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