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Solar-hybrid biocatalyst for methane hydroxylation to methanol
2025 / Nature CommunicationsMethane hydroxylation presents a promising approach to produce high-energy methanol from potent greenhouse gases, thereby contributing to a more sustainable future. Despite its environmental importance, current research on this process remains challenging due to the harsh operating conditions for the activation of inert C-H bond in methane. In nature, methane mon...
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Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases
2025 / Nature CommunicationsThe biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) involves binding of the N-terminal leader region of precursor peptides to peptide-modifying enzymes and subsequent modification of the C-terminal core. Canonical RiPP leaders are short and unstructured. However, atypical RiPP leaders called nitrile hydratase-like leader...
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Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction
2025 / Nature CommunicationsThe existence of linear cholesterol-recognition motifs in transmembrane domains has long been debated. Evolutionary molecular dynamics (Evo-MD) simulations—genetic algorithms guided by (coarse-grained) molecular force-fields–reveal that thermodynamic optimal cholesterol attraction in isolated alpha-helical transmembrane domains occurs when multiple co...
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Valuable Compounds from Pollutants: Converting PET into Enantiopure Alanine
2025 / ACS CatalysisThe enzymatic depolymerization of single-use plastic products, primarily made from poly(ethylene terephthalate) (PET), is now a reality. Herein, we report the development of an innovative tandem system process that uses engineered enzymes and Escherichia coli strains to depolymerize PET and convert the resulting products into enantiomers of alanine, useful amino ac...
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Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics
2025 / Nature Biomedical EngineeringGene-silencing mechanisms using RNA interference (RNAi) and antisense oligomers have drawn attention to nucleic acid medicines. However, several challenges remain such as low in vivo stability and inadequate target selectivity. Here we report a versatile and highly selective method for suppressing gene expression with a short oligonucleotide. The oligonucleotide,...
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ATR-FTIR and multivariate analysis for differential diagnosis of dengue and leptospirosis: a feasibility study
2025 / Scientific ReportsDengue and leptospirosis are prevalent diseases in tropical and subtropical regions, posing significant public health challenges. These illnesses exhibit overlapping symptoms, including fever, muscle pain, and headaches, which complicates diagnosis and delays appropriate treatment. This study explores the use of attenuated total reflectance-Fourier transform infr...
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Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction
2025 / Nature CommunicationsThe accumulation of intracellular aggregates of Tau protein is one main hallmark of Alzheimer’s disease (AD) and is the consequence of Tau conformational changes, increased phosphorylation, and self-association to form fibrillar aggregates. This pathological process prevents the physiological interaction of Tau with microtubules to the detriment of the stru...
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Effects of solution conditions on the self-assembly of the chaperone protein DNAJB6b
2025 / Communications ChemistryChaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone sel...
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Wet wipes from Citrus limon sanitizer and banana fiber nonwovens
2025 / Scientific ReportsWhereas sanitizing wipes are among the strategies for combatting COVID-19, there are growing concerns concerning their disposal, due to majority of them being made of non-biodegradable fibres. Additionally, majority of the sanitizing solutions used are associated with irritations and some are carcinogenic. In this study, banana wipes, impregnated with an organic ...
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Novel inducible nitric oxide synthase-inhibiting cytochalasins from an oyster-derived fungus Westerdykella dispersa Ca4-13: structural insights and molecular docking analysis
2025 / Botanical StudiesMarine-derived microorganisms are renowned for producing structurally diverse secondary metabolites with notable biological activities, serving as a promising reservoir for pharmaceutical development. In this study, the fungal strain Westerdykella dispersa Ca4-13, isolated from the edible oyster Crassostrea angulata, was investigated for its potential anti-inflamma...
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Agro-industrial by-products valorization for fructooligosaccharide production with Zymomonas mobilis
2025 / Bioresources and BioprocessingFructooligosaccharides (FOS) have gained attention due to their prebiotic properties and potential health benefits. This study explores the production of FOS using Zymomonas mobilis ZM4, a promising candidate for biotechnological processes, utilizing corn steep liquor (CSL) and sugarcane molasses as alternative and sustainable carbon and nitrogen sources. Two disti...
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Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation
2025 / Nature CommunicationsTriplet-triplet annihilation photon upconversion seeks efficient conversion of low-energy photons to high-energy emission. However, the triplet-triplet annihilation photon upconversion system faces limitations in emission gamut because efficient triplet-triplet energy transfer between sensitizer and annihilator relies on triplet energy matching, making it challen...
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Structural insights into light harvesting by antenna-containing rhodopsins in marine Asgard archaea
2025 / Nature MicrobiologyAquatic bacterial rhodopsin proton pumps harvest light energy for photoheterotrophic growth and are known to contain hydroxylated carotenoids that expand the wavelengths of light utilized, but these have not been characterized in marine archaea. Here, by combining a marine chromophore extract with purified archaeal rhodopsins identified in marine metagenomes, we ...
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The rechargeable battery using uranium as an active material
2025 / Scientific ReportsWe first demonstrate a nonaqueous rechargeable battery using uranium and iron as active materials. This uranium-iron battery achieves an open-circuit voltage of approximately 1.3 V, exhibits stable cycling performance, and delivers a good Coulombic efficiency of 86 ± 2%. These characteristics suggest a promising avenue for utilizing depleted ur...
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Functionalization of cotton fabric using bio-organic heat storage materials for human protection and thermal comfortability
2025 / Scientific ReportsIn this work, the synthesis of smart hosting materials from modified gelatin with different fatty acids (myristic acid, palmitic acid, and stearic acid) has been observed and characterized. Coconut oil was used as a natural phase change material (PCM) and octadecanol was used as an organic phase change material. Different concentrations of Phase change materials we...
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